Technical Articles

Myostatin

ActRIIB: The Negative Regulator Switch of Muscle Growth and Its Research Landscape

2026-09-20

ActRIIB is the type I receptor kinase for myostatin and activin signaling, writing the 'grow less muscle' instruction into the nucleus. This review covers its receptor structure, signaling axis, disease associations and in vitro research tools.

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Signaling Pathway
ActRIIB
Myostatin
Activin
SMAD2/3
Muscle growth
Inhibitor screening
UA079045

What is the GDF-8 target? Complete analysis of Myostatin molecular structure and signaling pathway

2026-06-30

Growth differentiation factor 8, abbreviated as GDF-8, commonly known as Myostatin in the industry, belongs to the TGF-β superfamily of secreted proteins. It is currently a core and highly popular target in the field of skeletal muscle regulation and was first identified in 1997 by a research team from a mouse skeletal muscle cDNA library.

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Metabolism
GDF-8
Myostatin
muscle growth inhibitor
GDF-8 target
TGF-β superfamily
skeletal muscle regulation
SMAD signaling pathway

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