Technical Articles

Multi-Target Agonists

In-depth Analysis of the GCGR Target: From the Hub of Glucose Metabolism to the Key Coreceptor for Multi-Target Metabolic Therapy

2026-06-23

The glucagon receptor (GCGR) is a crucial member of the class B G protein-coupled receptor family, forming a core receptor network with GLP-1R and GIPR to regulate glucose homeostasis and energy metabolism. The endogenous ligand of GCGR is glucagon, primarily secreted by pancreatic α-cells, which plays a pivotal role in maintaining fasting blood glucose levels, promoting lipid oxidation, and increasing energy expenditure.

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Immunity/Inflamma
GCGR
Glucagon Receptor
Class B GPCR
cAMP Signaling
Gluconeogenesis
Multi-Target Agonists
Metabolic Diseases

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