Technical Articles

This article systematically elucidates the "event-driven" pharmacological characteristics of molecular glue drugs, distinguishing them from traditional small molecules, by focusing on their mechanisms of action and therapeutic applications. It analyzes the molecular basis by which molecular glues induce the proximity of two proteins to form ternary complexes, thereby triggering target protein degradation, and explores the broad applications of chemically induced proximity effects in fields such as protein degradation, signal regulation, and gene editing.