Technical Articles

The glucagon receptor (GCGR) is a crucial member of the class B G protein-coupled receptor family, forming a core receptor network with GLP-1R and GIPR to regulate glucose homeostasis and energy metabolism. The endogenous ligand of GCGR is glucagon, primarily secreted by pancreatic α-cells, which plays a pivotal role in maintaining fasting blood glucose levels, promoting lipid oxidation, and increasing energy expenditure.

FGF-10, fully known as fibroblast growth factor-10, is a member of the FGF-7 subfamily within the FGF family. One of its most notable features is that it primarily functions through a paracrine mechanism, meaning it is secreted by mesenchymal cells and acts on neighboring epithelial cells.