Technical Articles

This article systematically elaborates on the clinical and basic research progress of MOG antibody-associated disease (MOGAD), presenting it as a novel inflammatory demyelinating disorder of the central nervous system distinct from multiple sclerosis and neuromyelitis optica spectrum disorders. It explores the molecular basis and pathogenesis of MOGAD, analyzes its age-dependent clinical manifestations, imaging features, and treatment strategies.

This article systematically elaborates on the molecular basis of MOG as a myelin component in the central nervous system and the demyelination process mediated by its autoantibodies, focusing on the pathological mechanisms and clinical features of MOG antibody-associated disease (MOGAD). It also analyzes the disease's incidence across different age groups, the diversity of clinical manifestations, and the patterns of recurrence.