Technical Articles

MAT1A

MAT1A: Catalytic Mechanism and Research Landscape of Methionine Adenosyltransferase

2026-09-23

MAT1A (EC 2.5.1.6) catalyzes methionine and ATP into SAM, the entry enzyme of one-carbon metabolism. This review covers its two-step catalytic mechanism, oligomeric states, division of labor with MAT2A, disease associations and in vitro research esse

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Metabolism
MAT1A
methionine adenosyltransferase
SAM
one-carbon metabolism
MAT I/III
isoenzymes
UA0800468

MAT1A: From the Hepatic Methylation Engine to a Turning Point in Tumor Metabolism

2026-09-23

MAT1A is the methylation engine of the liver, yet hepatocellular carcinoma cells systematically switch it off and re-express MAT2A. This article dissects the MAT1A/MAT2A switch, its consequence chain and the contest between two intervention routes fr

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Metabolism
MAT1A
SAM
one-carbon metabolism
MAT2A
hepatocellular carcinoma
methylation
UA0800468

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