Technical Articles

Lenalidomide

CRBN-DDB1 and Molecular Glues: From the Thalidomide Controversy to the New Paradigm of Targeted Degradation

2026-09-20

A once-withdrawn old drug revealed, sixty years later, an entirely new paradigm of targeted protein degradation. This article follows the timeline of how CRBN-DDB1 moved from the thalidomide mystery to center stage of molecular glue therapeutics.

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Drug Research
CRBN-DDB1
Molecular glue
Thalidomide
Lenalidomide
Targeted protein degradation
UA085062

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