Technical Articles

This article systematically elaborates on the molecular characteristics and biological functions of the Klotho protein, focusing on its structural features as an anti-aging gene-encoded product, its high expression patterns in the kidneys, and its mechanisms of renal protection through regulating phosphate metabolism, inhibiting oxidative stress, and suppressing inflammatory responses. It also analyzes its potential applications in ischemia-reperfusion injury, immunosuppressant-induced nephrotoxicity, and the protection of transplant kidney function.

The Klotho protein is a product encoded by the anti-aging gene Klotho, which was discovered in 1997 in a salt-sensitive hypertensive mouse model. Both human and mouse Klotho genes are located on chromosome 13.

The α-Klotho protein serves as a crucial geroprotective factor, playing a pivotal role in counteracting oxidative stress, hypoxia, and cytotoxic damage. Scientific evidence demonstrates that this protein effectively mitigates deleterious alterations associated with aging and various pathological conditions.