Technical Articles
Inhibitor screening
ActRIIB Inhibitor Screening: Turning Off the Brake Light of Muscle Growth
2026-09-20Picture the ActRIIB kinase assay as a brake light: the brighter the enzyme activity, the tighter the muscle brake. This article walks through the complete journey of an inhibitor from addition to readout in four acts.
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- Signaling Pathway
- ActRIIB
- Kinase assay
- Luminescence
- Inhibitor screening
- Experimental workflow
- UA079045
ActRIIB Kinase Inhibitor Screening: A Standard Workflow from Z' Factor to IC50
2026-09-20A tool-oriented guide to ActRIIB kinase inhibitor screening: ATP and enzyme concentration settings, control systems and Z' factor interpretation, luminescence interference checks and IC50 fitting considerations.
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- Signaling Pathway
- ActRIIB assay
- Kinase activity
- Inhibitor screening
- Z' factor
- IC50
- Luminescence
- UA079045
ActRIIB: The Negative Regulator Switch of Muscle Growth and Its Research Landscape
2026-09-20ActRIIB is the type I receptor kinase for myostatin and activin signaling, writing the 'grow less muscle' instruction into the nucleus. This review covers its receptor structure, signaling axis, disease associations and in vitro research tools.
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- Signaling Pathway
- ActRIIB
- Myostatin
- Activin
- SMAD2/3
- Muscle growth
- Inhibitor screening
- UA079045
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