Technical Articles

This article focuses on the molecular characteristics and biological functions of interleukin-5 (IL-5), systematically elaborating its core mechanism in immune checkpoint inhibitor therapy by driving systemic expansion of eosinophils and local tumor infiltration to enhance antitumor immune responses, analyzing the role of IL-5 in bone marrow eosinophilopoiesis and CD4+ T cell-dependent regulation, and exploring the clinical significance of the IL-5/IL-33 axis in immune cell synergy within the tumor microenvironment.