Technical Articles
IL-4R alpha
One Shared Subunit, Many Indications: How IL-4R alpha Anchors a Drug Pipeline
2026-10-21This article reviews how IL-4R alpha supports a string of indications from atopic dermatitis to asthma and COPD, and why target biology keeps it central in biologic pipelines.
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- Immunity/Inflamma
- IL-4R alpha
- dupilumab
- atopic dermatitis
- asthma
- Th2 inflammation
- biologic pipeline
- UA010382
IL-4R alpha Binding Assays: Where Flat Curves Usually Come From
2026-10-21A troubleshooting guide for IL-4R alpha binding experiments: receptor orientation, ligand pairing, coating format and control design when binding curves stay flat or fail to reach plateau.
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- Immunity/Inflamma
- binding assay
- IL-4R alpha
- CD124
- ELISA
- receptor-ligand pairing
- control design
- signal troubleshooting
- UA010382
IL-4R alpha/CD124: How One Shared Subunit Serves Both IL-4 and IL-13
2026-10-21IL-4R alpha (CD124) is the common subunit of the type I and type II IL-4 receptor complexes. This article explains how one receptor chain accommodates both IL-4 and IL-13 signaling.
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- Immunity/Inflamma
- IL-4R alpha
- CD124
- IL-4
- IL-13
- type II receptor
- STAT6
- Th2
- receptor complex
- UA010382
- 1
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