Technical Articles

IGF1R protein

IGF1R Protein: The Core Receptor of the Insulin-like Growth Factor Signaling Axis and a Key Molecule for Tumor-Targeted Therapy

2026-10-22

This article focuses on the molecular characteristics and biological functions of insulin-like growth factor 1 receptor (IGF1R/CD221), systematically elaborating its structural composition and ligand activation mechanism as a tetrameric transmembrane receptor tyrosine kinase, analyzing the signaling network through which IGF1R regulates cell proliferation, survival, metastasis, and angiogenesis via the PI3K-AKT and RAS-RAF-MEK-ERK pathways, and exploring the overexpression of IGF1R in various malignant tumors and its association with resistance to antitumor drugs.

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Signaling Pathway
IGF1R protein

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