Technical Articles

This article systematically elucidates the central role of IFN-γR1 (IFNGR1) as the constitutive binding subunit of the IFN-γ signaling pathway in the antimicrobial immunity of macrophages, focusing on the composition and function of the type II interferon receptor. It also analyzes the molecular mechanism by which IFN-γR2 translocates from the cytoplasm to the cell membrane under infectious conditions and its decisive role in the assembly of functional receptors.