Technical Articles

This article systematically elucidates the molecular characteristics and biological functions of IFN-γ, focusing on its role as a key effector molecule driving anti-tumor immune responses following T cell activation, and analyzes the value of its downstream signaling features as predictive biomarkers for the clinical efficacy of immune checkpoint inhibitors.

CAR-T therapy has demonstrated promising efficacy in patients with hematologic malignancies, but it is often accompanied by clinical toxicities such as cytokine release syndrome, which not only affects patient health but also increases the medical burden.

IFN-γ protein is the sole member of the type II interferon family, primarily produced by activated T cells, natural killer cells, and NKT cells. This protein binds to the receptor complex composed of IFNGR1 and IFNGR2 subunits on the cell surface, activating the JAK-STAT signaling pathway and regulating the expression of multiple genes.