Technical Articles

This article systematically elaborates on the core functions of follicular helper T (TFH) cells under physiological and pathological conditions, analyzes the molecular basis of their phenotypic heterogeneity and functional plasticity, explores the dual roles of TFH cells in infection immunity, tumor surveillance, and autoimmune diseases, and summarizes current strategies for targeting TFH cell regulation. On this basis, it illustrates the application of T cell polarization research tools in related experiments.