Technical Articles

This article focuses on the molecular characteristics and biological functions of HBS1L, systematically elaborating its molecular mechanisms as a translational GTPase that forms a complex with PELO to recognize stalled ribosomes, dissociate ribosomal subunits, and initiate the nonsense-mediated decay pathway. It analyzes its initiating role in ribosome-associated quality control and the physiological significance of clearing abnormal mRNAs and incomplete polypeptides, and explores the disease associations of HBS1L in FOCAD-deletion synthetic lethality in tumors, hemoglobin regulation, and hereditary eye diseases.