Technical Articles

This article focuses on the specific high expression and glucose metabolism regulatory function of glutathione S-transferase Pi 1 (GSTP1, also referred to as GSPT1 in the text) in triple-negative breast cancer, systematically elaborating the discovery process of its role as a key regulatory factor in glycolysis metabolism in triple-negative breast cancer cells, analyzing the molecular mechanisms by which small-molecule inhibitors targeting this target damage tumor cell growth through inhibiting GAPDH activity and its downstream metabolic pathways and signaling pathways, and discussing the potential value of this target in targeted therapy for triple-negative breast cancer.