Technical Articles

GPC3 is a member of the GPI-anchored heparan sulfate proteoglycan family. This review covers its molecular structure, the Xq26.2 gene locus, its developmental-adult-tumor expression profile, and the panorama of liver cancer targeted research.

GPC3 expression regulation plays out like a three-act drama: a debut in the embryo, a curtain call in adulthood, and a loss-of-control restart in hepatocellular carcinoma, with an overgrowth interlude in between. This article unpacks the logic of GPC

The main challenges of PE-labeled GPC3 flow cytometry are control design and compensation. This article reviews the QC evidence of PE-labeled GPC3 antigen, a CAR-positive cell verification system, the logic of a five-control panel, and troubleshootin

This article will provide an in-depth analysis of Alexa Fluor 647-Labeled GPC3 His Tag protein—an advanced bioconjugate. We will elaborate on its composition, working principles, and focus on its profound association with major diseases such as hepatocellular carcinoma (HCC), demonstrating its pivotal role in precision cancer diagnosis, drug development, and immunotherapy.

GPC3 (Glypican-3) is a glycoprotein located on the surface of cell membranes, belonging to the heparan sulfate proteoglycan family. Its gene is located in the q26.1 region of the human X chromosome, encoding a protein consisting of 580 amino acids with a molecular weight of approximately 70 kDa.