Technical Articles

This article focuses on the molecular characteristics and neuroimmunomodulatory functions of growth differentiation factor 15 (GDF-15), systematically elaborating the association between elevated GDF-15 levels during pregnancy and reduced relapse rates in multiple sclerosis. It analyzes the molecular mechanism by which GDF-15 activates the "brain-spleen axis" sympathetic nerve signaling through the brainstem GFRAL receptor, thereby inhibiting the migration of autoreactive T cells. Additionally, it explores the therapeutic potential of GDF-15 recombinant protein in neuroinflammatory interventions.