Technical Articles

This article focuses on the molecular characteristics and splicing regulatory mechanisms of the fibronectin EDA and EDB domains, systematically elaborating the structural differences and functional differentiation of the three forms of fibronectin—plasma fibronectin, cellular fibronectin, and fetal fibronectin—analyzing the molecular basis for the overexpression of the EDA and EDB domains in embryonic tissues, placental tissues, and malignant cells, and exploring the clinical value of EDA/EDB as tumor-specific markers and targeted therapeutic targets.