Technical Articles

This article focuses on the molecular characteristics and biological functions of the neonatal Fc receptor (FcRn), systematically elaborating its core role in extending the half-life of IgG and human serum albumin through pH-dependent mechanisms, analyzing the application strategies of FcRn in autoimmune disease treatment, antibody drug half-life extension, and albumin fusion drug development, and exploring the bidirectional association between aberrant FcRn expression and tumor progression in cancer.