Technical Articles

This article systematically elucidates the molecular characteristics and functional mechanisms of Syndecan-1 (CD138) as a member of the heparan sulfate proteoglycan family. It focuses on how Syndecan-1 is regulated to the cell membrane surface via the MAPK-PSD4-ARF6 axis in KRAS mutation-driven pancreatic ductal adenocarcinoma, thereby mediating macropinocytosis to support tumor metabolic reprogramming.