Technical Articles

This article focuses on the molecular characteristics and biological functions of fibroblast growth factor 23 (FGF-23), systematically elaborating its core regulatory role as a phosphaturic hormone in mineral metabolism disorders in chronic kidney disease, analyzing the interaction mechanisms between FGF-23 and calcium and phosphorus metabolism as well as the clinical significance of the signaling axis formed with Klotho in the progression of CKD, and exploring the application prospects of FGF-23 as a new target for the diagnosis and treatment of CKD.