Technical Articles

This article systematically elaborates on the physiological functions of fibroblast growth factor 23 (FGF-23) as a phosphaturic hormone and its pathological significance in chronic kidney disease (CKD). It analyzes key evidence demonstrating that FGF-23 undergoes early alterations in CKD and serves as a sensitive indicator of phosphorus retention. Additionally, it explores the mechanisms by which FGF-23 mediates cardiovascular damage through "off-target" effects and discusses its potential value as a therapeutic target.

In the exploration of kidney health, various factors are intertwined and affect the health of patients. Among them, FGF-23 has gradually entered the public's field of vision and become the focus of scientists' research. It is closely related to the health of maintenance dialysis patients, especially the occurrence of hypotension.