Technical Articles

This article systematically elaborates on the molecular characteristics and biological functions of fibroblast growth factor 21 (FGF-21), highlighting its multifaceted role as a core regulator of energy homeostasis in the liver, skeletal muscle, pancreas, and heart. It analyzes the mechanisms by which FGF-21 exerts metabolic regulation through promoting glucose utilization, fatty acid oxidation, and anti-inflammatory signaling pathways.

Fibroblast growth factor 21 (FGF-21) is an endocrine metabolic regulator within the fibroblast growth factor family. Since its discovery, this protein has emerged as a cutting-edge research focus in the field of metabolic diseases due to its unique roles in glucose and lipid metabolism, energy homeostasis regulation, and improvement of insulin sensitivity.