Technical Articles

Epigenetics

The Ledger of a Single Methyl Group: How NNMT Rewrites Cellular Methylation Capacity

2026-09-20

Picture the NNMT reaction as an accounting exercise: SAM is the wallet, SAH the IOU, and histone methylation is where the money is spent. This article walks through the bookkeeping and reconciliation of this methyl ledger in four steps.

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Metabolism
NNMT
SAM
SAH
Histone methylation
Epigenetics
Metabolite quantification
UA085036

Why NNMT Appears at the Frontier of Both Cancer and Obesity Research

2026-09-20

The same 29 kDa cytosolic enzyme is used by tumors to rewrite epigenetics and by adipose tissue to link with obesity. This article dissects the mechanism evidence and translational progress of NNMT along both disease lines.

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Metabolism
NNMT
Cancer metabolism
1-MNA
Obesity
Insulin resistance
Epigenetics
UA085039

NNMT: An Epigenetic Switch on the Nicotinamide Metabolic Branch

2026-09-20

NNMT catalyzes nicotinamide and SAM into 1-MNA and SAH, connecting the NAD+ salvage pathway with methylation metabolism. This review covers its catalytic mechanism, epigenetic effects, disease associations and in vitro research essentials.

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Metabolism
NNMT
Nicotinamide N-methyltransferase
1-MNA
SAM
Epigenetics
Cancer metabolism
UA085039

靶向Bromodomain非催化保守残基的活性探针设计及其在表观遗传研究试剂盒中的应用

Design of Active Probes Targeting Non-Catalytic Conserved Residues of Bromodomain and Their Application in Epigenetic Research Kits

2026-01-06

The Bromodomain (BRD) family proteins, as key epigenetic "readers" that recognize histone acetylated lysine (KAc), play a regulatory role in diseases such as cancer.

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Cancer
Epigenetics Bromodomain Kit
Epigenetics
Protein acetylation

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