Technical Articles

This article focuses on the molecular characteristics and biological functions of extracellular signal-regulated kinase 2 (ERK2), systematically elaborating its pivotal role as a core component of the MAPK/ERK cascade in the dual-site phosphorylation activation mechanism, nuclear translocation regulation, and phosphorylation of various substrates. It also analyzes the pathological significance of the RAS-RAF-MEK-ERK signaling axis in tumorigenesis.