Technical Articles

MOG (myelin oligodendrocyte glycoprotein) is a myelin protein and a recurring autoimmune target. This article explains its localization, IgV ectodomain, antibody epitopes and functional readouts.

MOG (1-125) is the extracellular IgV domain of myelin oligodendrocyte glycoprotein. This article explains its truncation range, immunodominant epitopes, glycosylation effect, and the EAE induction workflow.

Multiple Sclerosis (MS) is a classic autoimmune disease whose pathological mechanisms are not yet fully understood. To further investigate and comprehend the pathogenesis of MS, researchers widely employ the Experimental Autoimmune Encephalomyelitis (EAE) animal model. In these models, Myelin Oligodendrocyte Glycoprotein (MOG) is utilized as an immunogen to induce autoimmune lesions, mimicking the progression of MS. This article reviews the establishment and characteristics of the MOG-induced EAE animal model, its applications in studying autoimmune diseases, and explores the potential role of this model in elucidating the pathophysiology of MS.