Technical Articles

E3 ubiquitin ligase
CRBN-DDB1 复合物：CRL4 泛素连接酶的底物识别核心
The CRBN-DDB1 Complex: Substrate-Recognition Core of the CRL4 Ubiquitin Ligase
发布时间 2026-09-20
As the substrate receptor of the CRL4 E3 ubiquitin ligase, CRBN relies on DDB1 to bridge the Cullin4-RBX1 core for ubiquitin transfer. This article systematically dissects the complex assembly logic, molecular glue mechanisms and in vitro research es
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  • Drug Research
  • CRBN-DDB1
  • Molecular glue
  • E3 ubiquitin ligase
  • CRL4
  • Substrate receptor
  • UA085062
Total 1
  • 1
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