Technical Articles

DcR3

DcR3: From Driver of Tumor Immune Evasion to Inflammation Brake—Translational Prospects of a Two-Faced Target

2026-09-20

DcR3 promotes immune escape in the tumor microenvironment while acting as inhibitory feedback in chronic inflammation. This article reviews its bidirectional mechanisms, sources of expression regulation, variable-control essentials on both research f

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Immunity/Inflamma
DcR3
Tumor immune evasion
Chronic inflammation
Immunosuppression
Biomarker
UA019076

The Immune System's Decoy Keys: How DcR3 Intercepts Three Death Signals

2026-09-20

As a soluble decoy receptor, DcR3 intercepts FasL, LIGHT and TL1A one after another. Following the process of ligand departure, key swap and signal shutdown, this article dissects the decoy mechanism and the logic of its experimental validation.

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Immunity/Inflamma
DcR3
Decoy receptor
FasL
LIGHT
TL1A
Tumor immune evasion
UA019076

The protective mechanism of DcR3 in sepsis: from inflammation suppression to gut microbiota regulation

2026-07-29

This article systematically elaborates the multiple protective effects of decoy receptor 3 (DcR3) in animal models of sepsis, analyzing its molecular mechanisms in inhibiting inflammatory responses, regulating immune cell composition, protecting the intestinal barrier, and modulating gut microbiota.

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Immunity/Inflamma
DcR3

Total 3

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