Technical Articles

This article focuses on the molecular characteristics and biological functions of death receptor 3 (DR3/TNFRSF25), systematically elaborating its molecular mechanism as a type I transmembrane glycoprotein that specifically binds the ligand TL1A through its extracellular cysteine-rich domain and recruits the adaptor protein TRADD through its intracellular death domain to activate downstream NF-κB and MAPK signaling pathways, analyzing the bidirectional immunoregulatory role of DR3 in maintaining regulatory T cell homeostasis and promoting pathogenic Th17 differentiation, and exploring the multifaceted therapeutic potential of DR3 in autoimmune diseases, transplant rejection, inflammatory bowel disease, and tumor immunity.