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DNA-binding domain
P53：为何被称为基因组的守护者，又如何成为肿瘤治疗的难题？
P53: Guardian of the Genome and a Persistent Challenge in Cancer Therapy
发布时间 2026-10-10
P53 (TP53) is the most studied tumor suppressor. This article breaks down its domain architecture, stress-activation mechanism, hotspot mutation spectrum, and the functional readouts and experimental interfaces commonly used in tumor research.
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  • Cancer
  • P53
  • TP53
  • tumor suppressor
  • DNA damage
  • DNA-binding domain
  • hotspot mutation
  • MDM2
  • apoptosis
  • UA085067
Total 1
  • 1
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