Technical Articles

DKK-1 binds LRP5/6 and Kremen to block Wnt signaling. This article explains the brake mechanism, bone and cancer contexts and how recombinant DKK-1 supports Wnt studies.

Dickkopf-1 protein is a key endogenous inhibitor of the Wnt/β-catenin signaling pathway, hailed as the "molecular brake" of bone metabolism. It plays a central regulatory role in embryonic development, bone formation, and tissue homeostasis.

Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a rare genetic connective tissue disorder with an incidence of approximately 1/10,000 to 1/20,000. Patients often present with low bone mass, increased bone fragility, recurrent fractures, and may exhibit extra-skeletal manifestations such as blue sclerae, hearing loss, and dentinogenesis imperfecta.