Technical Articles

Cytoskeletal disease

Skin Fragility, Neuropathy and Tumor Metastasis: Three Lines of Defense Lost When Plectin Fails

2026-09-20

Loss of Plectin function follows one main thread—cytoskeletal cross-link failure leading to tissue mechanical fragility—manifesting as EBS-MD, peripheral neuropathy and mechanically driven tumor metastasis in different tissues. This article dissects

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Cell Biology
Plectin
Epidermolysis bullosa simplex
Cytoskeletal disease
Mechanotransduction metastasis
NHP model
UA016101

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