Technical Articles

This article systematically elucidates the molecular structure of IL-27 as a member of the IL-6/IL-12 family, its signal transduction mechanisms, and its complex regulatory functions in tumor immunity, autoimmune diseases, obesity-related inflammation, and viral infections. It reveals its dual effects mediated through the JAK/STAT pathway—both anti-tumor and pro-tumor—as well as its context-dependent anti-inflammatory and pro-inflammatory characteristics.