Technical Articles
Cancer metabolism
Why NNMT Appears at the Frontier of Both Cancer and Obesity Research
2026-09-20The same 29 kDa cytosolic enzyme is used by tumors to rewrite epigenetics and by adipose tissue to link with obesity. This article dissects the mechanism evidence and translational progress of NNMT along both disease lines.
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- Metabolism
- NNMT
- Cancer metabolism
- 1-MNA
- Obesity
- Insulin resistance
- Epigenetics
- UA085039
NNMT: An Epigenetic Switch on the Nicotinamide Metabolic Branch
2026-09-20NNMT catalyzes nicotinamide and SAM into 1-MNA and SAH, connecting the NAD+ salvage pathway with methylation metabolism. This review covers its catalytic mechanism, epigenetic effects, disease associations and in vitro research essentials.
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- Metabolism
- NNMT
- Nicotinamide N-methyltransferase
- 1-MNA
- SAM
- Epigenetics
- Cancer metabolism
- UA085039
- 1
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