Technical Articles

GPC3 is a member of the GPI-anchored heparan sulfate proteoglycan family. This review covers its molecular structure, the Xq26.2 gene locus, its developmental-adult-tumor expression profile, and the panorama of liver cancer targeted research.

GPC3 expression regulation plays out like a three-act drama: a debut in the embryo, a curtain call in adulthood, and a loss-of-control restart in hepatocellular carcinoma, with an overgrowth interlude in between. This article unpacks the logic of GPC

The main challenges of PE-labeled GPC3 flow cytometry are control design and compensation. This article reviews the QC evidence of PE-labeled GPC3 antigen, a CAR-positive cell verification system, the logic of a five-control panel, and troubleshootin

This article breaks down stress granule assembly and mRNA translation regulation in four steps - mRNA storage, stress signaling, granule assembly and clearance - centered on the regulatory role of Caprin-1 and its interplay with G3BP1, autophagy and

The key challenges of Caprin-1 binding assays are sequence alignment across three species and interpretation of anomalous migration. This article reviews QC evidence of CHO-expressed Caprin-1, ELISA EC50 benchmarks, SPR/BLI parameters and the logic o

Caprin-1 is both a cytosolic RNA-binding protein of stress granules and a membrane-expressed pan-cancer target. This article follows the translational storyline through its disease spectrum, miRNA regulation and the clinical development of TRK-950 fr

This article systematically elaborates on the molecular characteristics and biological functions of glypican-3 (GPC3), focusing on its specific high expression pattern as an oncofetal antigen in hepatocellular carcinoma (HCC) and its mechanisms of involvement in tumorigenesis and progression through the regulation of Wnt, FGF-2, and other signaling pathways. It also analyzes its multifaceted application value in HCC diagnosis, imaging, and immunotherapy.

This article focuses on the molecular characteristics and biological functions of prostate-specific membrane antigen (PSMA), systematically elaborating its structural features as a type II transmembrane glycoprotein and its specific high expression pattern in prostate cancer cells, while analyzing its core value in the diagnosis, staging, efficacy evaluation, and targeted therapy of prostate cancer.

This article systematically elucidates the molecular characteristics and biological functions of protein tyrosine kinase 7 (PTK7), focusing on its role as an inactive receptor tyrosine kinase in the co-receptor mechanisms of the Wnt and VEGF signaling pathways. It analyzes its low-level expression in normal tissues and its aberrant overexpression in various malignant tumors.

This article systematically elaborates on the molecular characteristics and immune functions of the CD24/Siglec-10 signaling axis, highlighting its pivotal role as a "don't eat me" signal in tumor immune evasion. It analyzes its complementary value in CD47 inhibitor-resistant tumors and introduces the application of human CD24 recombinant protein in related research.