Technical Articles

This article focuses on the molecular characteristics and biological functions of the chemokine CXCL4/platelet factor 4, systematically elucidating its central role as an inflammatory regulator and fibrosis driver in primary myelofibrosis. It analyzes the molecular mechanisms by which CXCL4 promotes bone marrow fibrosis through hematopoietic-stromal cross-talk and explores the therapeutic potential of targeting CXCL4 to alleviate inflammation in myelofibrosis.