Technical Articles

CHI3L1 (YKL-40) is a secreted glycoprotein of the glycoside hydrolase 18 family without enzymatic activity. This review covers its molecular features, receptor signaling network, attributes as a serum biomarker, and disease associations including ast

This article breaks down the molecular events of CHI3L1 in tissue repair and the tumor microenvironment in four steps: alarm signaling, matrix remodeling, immune polarization toward Th2 responses, and angiogenesis.