Technical Articles

This article focuses on the molecular characteristics and tumor biological functions of CUB domain-containing protein 1 (CDCP1), systematically elaborating its structural composition as a type I single-pass transmembrane glycoprotein, the regulatory mechanisms of proteolytic cleavage, and the functional significance of the neo-epitope generated after cleavage. It analyzes the context-dependent dual functional profile of CDCP1 in promoting invasion and metastasis versus suppressing metastasis, and discusses the levels of evidence and key considerations regarding its tumor expression profile, prognostic assessment, and targeted therapeutic development.