Technical Articles
CD221
IGF1R/CD221: Structure, alpha2beta2 Assembly and the Tumor Research Landscape of a Receptor Tyrosine Kinase
2026-10-08IGF1R/CD221 is a receptor tyrosine kinase of the insulin receptor family, assembled as an alpha2beta2 heterotetramer. This review covers its molecular architecture, IGF-1/IGF-2 ligand recognition, PI3K-AKT and RAS-RAF-MEK-ERK signaling, and key point
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- Cancer
- IGF1R
- CD221
- alpha2beta2
- RTK
- IGF-1
- IGF-2
- PI3K/AKT
- RAS/RAF/MEK/ERK
- UA016082
CD221/IGF1R Fc Chimeric Protein Binding Assays: Ligands, Conditions and Interpretation
2026-10-08CD221/IGF1R Fc chimeric protein is a research tool for IGF-2 binding studies. This article covers Fc fusion design, HEK293-derived antigen QC, ELISA platform parameters and a three-class control troubleshooting path.
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- Cancer
- CD221
- IGF1R
- Fc chimeric protein
- IGF-2 binding
- ELISA
- EC50
- UA016082
- alpha2beta2
- RTK
- 1
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