Technical Articles

This article systematically elaborates on the molecular characteristics and biological functions of B-cell activating factor (BAFF), a member of the TNF ligand family, detailing its signaling network that regulates B-cell survival, proliferation, and differentiation through three receptors. It analyzes the pathogenic role of BAFF in autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis, and explores the application strategies of BAFF recombinant proteins in B-cell function research and targeted drug development.