Technical Articles

This article focuses on the molecular characteristics and immunoregulatory functions of B7-H3 (CD276), systematically elaborating its protein structure as a member of the B7 immune costimulatory and coinhibitory family, the compositional differences between its two isoforms, and its bidirectional regulatory role in adaptive immunity. It analyzes the restricted expression of B7-H3 in normal tissues and its widespread high expression in various primary malignant tumors, and explores its pathological role in promoting tumor progression through immunosuppressive and non-immune mechanisms.