Technical Articles

This article focuses on the molecular characteristics and biological functions of the androgen receptor ligand-binding domain (AR-LBD), systematically elaborating its molecular mechanism as a member of the nuclear receptor superfamily in triggering conformational changes and activating transcription through androgen binding, analyzing the bidirectional structural communication between the AF2 hydrophobic surface and the ligand-binding pocket and its role in coactivator recruitment, and exploring the association of AR-LBD gene mutations with prostate cancer drug resistance and androgen insensitivity syndrome.