Technical Articles

This article focuses on the molecular characteristics and autophagy regulatory functions of ATG4B, systematically elaborating its core role as the only specific cysteine protease of the Atg8 family in LC3 precursor cleavage and LC3-II delipidation, analyzing the molecular mechanism by which UBE3C modifies ATG4B Lys119 via K33-branched ubiquitin chains to regulate its activity without inducing degradation, and exploring the fine regulation of the autophagy pathway by ATG4B ubiquitination under normal and starvation conditions.