Technical Articles

ASC37

GLP-1R/GIPR/GCGR: From Single-Target Agonism to a Triple-Target Synergistic Paradigm for Metabolic Therapy

2026-06-23

Glucagon-like peptide-1 receptor (GLP-1R) agonists have revolutionized the treatment of type 2 diabetes and obesity over the past decade. However, the efficacy ceiling of single-target drugs and gastrointestinal tolerance issues have prompted researchers to explore more complex multi-target synergistic strategies.

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Immunity/Inflamma
Keywords: GLP-1R
GIPR
GCGR
triple agonist
tirzepatide
retatrutide
ASC37
multi-target agonist
obesity
type 2 diabetes

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