Technical Articles

This article focuses on the molecular characteristics and signal transduction functions of activin receptor type IIA (ACVR2A), systematically elaborating the molecular mechanisms by which it, as a type II receptor serine/threonine kinase of the TGF-β superfamily, regulates three major physiological processes—erythropoiesis, skeletal muscle mass, and lipid metabolism—through binding to ligands such as activin, myostatin, and GDF11; analyzing its overactivation in ineffective erythropoiesis in β-thalassemia and myelodysplastic syndromes and the therapeutic principles of ligand trap strategies; and exploring its expanded application prospects in pulmonary arterial hypertension, preeclampsia, and metabolic diseases.